Abstract
Purpose:
To report a case of ocular surface squamous neoplasia (OSSN) that resolved with topical Aloe vera eye drop treatment.
Methods:
A 64-year-old Hispanic woman with a lesion typical for OSSN in her left eye was followed up with multiple clinical examinations and ocular surface photographs to document changes over time with A. vera-based topical treatment.
Results:
The patient refused biopsy of her lesion and traditional treatments and, instead, initiated using A. vera eye drops 3 times daily. At follow-up visits, the lesion was noted to regress until it finally resolved 3 months after commencing treatment. No additional topical medications were used, and she has remained tumor free for 6 years.
Conclusions:
Ongoing research is warranted because A. vera may represent a new therapeutic class of medications for OSSN treatment.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Administration, Topical
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Allantoin / administration & dosage
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Allantoin / therapeutic use*
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Aloe / chemistry*
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use*
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Carcinoma in Situ / drug therapy*
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Carcinoma in Situ / pathology
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Conjunctival Neoplasms / drug therapy*
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Conjunctival Neoplasms / pathology
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Corneal Diseases / drug therapy*
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Corneal Diseases / pathology
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Female
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Humans
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Middle Aged
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Ophthalmic Solutions
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Parabens / administration & dosage
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Parabens / therapeutic use
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Phytotherapy*
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Preservatives, Pharmaceutical / administration & dosage
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Preservatives, Pharmaceutical / therapeutic use
Substances
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Antineoplastic Agents
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Ophthalmic Solutions
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Parabens
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Preservatives, Pharmaceutical
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Allantoin
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methylparaben